High Alert
Clostridium difficile PCR ribotype 027: assessing the risks of further worldwide spread
Clements ACA et al. – This framework first requires identification of potential vehicles of introduction, including international transfers of hospital patients, international tourism and migration, and trade in livestock, associated commodities, and foodstuffs. It then calls for assessment of the risks of pathogen release, of exposure of individuals if release happens, and of resulting outbreaks. Health departments in countries unaffected by outbreaks should assess the risk of introduction or reintroduction of C difficile PCR ribotype 027 using a structured risk–assessment approach. read more
Most Recent Posts
Emergence and Dissemination of Extended-Spectrum beta-Lactamase–Producing Escherichia coli in the Community: Lessons from the Study of a Remote and Controlled Population
Woerther PL et al. – In this population, the frequency of ESBL increased with time because of the appearance of CTX–M ESBL, mimicking what occurs in the developed world. This resulted from the probable repeated introduction of new strains and plasmids and from interindividual dissemination. During the same period, antibiotic use substantially increased.
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Multidrug resistant Acinetobacter baumannii: a descriptive study in a city hospital
Multidrug resistant Acinetobacter baumannii, (MRAB) is an important cause of hospital acquired infection. The purpose of this study is to determine the risk factors for MRAB in a city hospital patient population read more
Epidemic meticillin-resistant Staphylococcus aureus (EMRSA-15) variants detected in healthy and diseased individuals in India
Nadig S et al. – All isolates were positive for Panton–Valentine leukocidin and toxic shock syndrome toxin, which is a cause for concern. In addition to soft–tissue infections, the EMRSA–15 isolates from patients were also responsible for meningitis and brain abscesses, which is quite rare.
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Predicting Bacteremia among Patients Hospitalized for Skin and Skin‐Structure Infections: Derivation and Validation of a Risk Score
Lipsky BA et al. – Using data available at hospital admission, the authors developed a risk score that differentiated SSSI patients at low risk for bacteremia from patients at high risk. This score may help clinicians identify patients who require more intensive monitoring or antimicrobial regimens appropriate for treating bacteremia. read more
Relationship of Vancomycin MIC to Mortality in Patients with Methicillin-Resistant Staphylococcus aureus Hospital-Acquired, Ventilator-Associated and Healthcare-Associated Pneumonia
Haque NZ et al. – Mortality in patients with MRSA HAP, VAP, and HCAP increases as a function of the vancomycin MIC even for strains with MIC values within the susceptible range. Evaluation of vancomycin MICs should be contemplated at the institutional level and for individual cases of MRSA pneumonia. The use of vancomycin therapy in patients with MRSA pneumonia caused by isolates with MICs between 1 and 2 (mu)g/mL should be undertaken with caution and alternative therapies should be considered. read more
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