SBN: Dr. White, DPM

July 29th, 2010

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High Alert

Antibiotics in the clinical pipeline in 2011

May 22nd, 2011

Butler MS et al. – The emergence of multi–drug–resistant bacteria and the lack of new antibiotics in the antibiotic drug development pipeline, especially those with new modes of action, is a major health concern. read more

Telavancin shows superior activity to vancomycin with multidrug-resistant Staphylococcus aureus in a range of in vitro biofilm models

May 21st, 2013

Smith K et al. – The activity of telavancin was compared with vancomycin against methicillin–resistant Staphylococcus aureus (MRSA) in planktonic culture and biofilms grown using a range of in vitro models. Despite differences between the models evaluated, telavancin typically demonstrated improved efficacy over vancomycin, indicating the potential value of the agent in the treatment of biofilm–mediated infections caused by S. aureus, especially multidrug–resistant isolates.

European Journal of Clinical Microbiology & Infectious Diseases, 05/10/2013 Clinical Article

Staphylococcus aureus Leukotoxin GH Promotes Inflammation

September 5th, 2012

Malachowa N et al. – The findings indicate that S. aureus leukotoxins enhance the host inflammatory response and influence the outcome of infection. read more

Acquisition of spores on gloved hands after contact with the skin of patients with Clostridium difficile infection and with environmental surfaces in their rooms.

September 5th, 2012

Guerrero DM, Nerandzic MM, Jury LA, Jinno S, Chang S, Donskey CJ.
Source University Hospitals of Cleveland Case Medical Center, Cleveland, OH. read more

How Staphylococcus aureus Breaches Our Skin to Cause Infection

June 14th, 2012

Otto M – Recent extensive research on USA300 virulence factors identified a series of molecular determinants that affect the capacity of this clone to cause abscess formation in experimental models. read more

Low level SZ-lactamase production in methicillin resistant staphylococcus aureus strains with SZ-lactam antibiotics-induced vancomycin resistance

June 14th, 2012

Hirao Y et al. – Authors concluded that BIVR cells gain vancomycin resistance by the elimination or inactivation of SZ–lactamase production, thereby preserving SZ–lactam antibiotics in milieu, stimulating peptidoglycan metabolism, and depleting free vancomycin to a level below the minimum inhibitory concentration of vancomycin.

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