High Alert
Antibiotics in the clinical pipeline in 2011
Butler MS et al. – The emergence of multi–drug–resistant bacteria and the lack of new antibiotics in the antibiotic drug development pipeline, especially those with new modes of action, is a major health concern. read more
Most Recent Posts
Staphylococcus aureus Leukotoxin GH Promotes Inflammation
Malachowa N et al. – The findings indicate that S. aureus leukotoxins enhance the host inflammatory response and influence the outcome of infection. read more
Acquisition of spores on gloved hands after contact with the skin of patients with Clostridium difficile infection and with environmental surfaces in their rooms.
Guerrero DM, Nerandzic MM, Jury LA, Jinno S, Chang S, Donskey CJ.
Source University Hospitals of Cleveland Case Medical Center, Cleveland, OH. read more
How Staphylococcus aureus Breaches Our Skin to Cause Infection
Otto M – Recent extensive research on USA300 virulence factors identified a series of molecular determinants that affect the capacity of this clone to cause abscess formation in experimental models. read more
Low level SZ-lactamase production in methicillin resistant staphylococcus aureus strains with SZ-lactam antibiotics-induced vancomycin resistance
Hirao Y et al. – Authors concluded that BIVR cells gain vancomycin resistance by the elimination or inactivation of SZ–lactamase production, thereby preserving SZ–lactam antibiotics in milieu, stimulating peptidoglycan metabolism, and depleting free vancomycin to a level below the minimum inhibitory concentration of vancomycin.
Staphylococcal decolonisation: an effective strategy for prevention of infection?
Simor AE – The efficacy of decolonisation of patients with community–associated MRSA has not been established, and the routine use of decolonisation of non–surgical patients is not supported by data. read more
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