A comparison of linezolid with glycopeptides in severe MRSA pneumonia

October 14th, 2009

Abunasser J et al. – The results showed a survival benefit only for linezolid, despite the fact that all three antibiotics had levels above MIC in all the compartments sampled, leading them to speculate that linezolid may have improved outcomes by mechanisms not directly related to its antimicrobial actions. read more

Management of the Catheter in Documented Catheter-Related Coagulase-Negative Staphylococcal Bacteremia: Remove or Retain

October 7th, 2009

Raad I et al. – CVC retention does not have an impact on the resolution of coagulase–negative staphylococcal bacteremia but is a significant risk factor of recurrence. read more

Antimicrobial susceptibility of Gram-positive bacteria isolated from US medical centers: results of the Daptomycin Surveillance Program (2007–2008)

October 7th, 2009

Sader HS et al. – High rates of methicillin–resistant staphylococci and vancomycin–resistant enterococci were observed in US hospitals, but daptomycin remains active against these clinically important Gram–positive organisms with no evidence of potency loss since its approval for clinical use in late 2003. read more

Acinetobacter baumannii-Associated Skin and Soft Tissue Infections: Recognizing a Broadening Spectrum of Disease

October 2nd, 2009

Guerrero DM et al. – As the prevalence of A. baumannii continues to increase in the health care system, SSTIs caused by this organism may become more common. Clinicians must be aware that the spectrum of disease caused by A. baumannii could include severe necrotizing SSTI and that vigilance for potential complications is necessary. read more

Antibiotic resistance in clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus does not impact sensitivity to human beta defensin 4

October 2nd, 2009

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