December 30th, 2009
Verweij PE et al. – The authors recognize that additional work will be needed to confirm these proposed breakpoints, including in vivo and clinical correlative responses. The authors also propose nomenclature for genotypic resistance, in the event an isolate is not cultured, typified by ITZgR, VCZgI, POSgR (G54W) indicating that the isolate has a G54W substitution with a corresponding phenotype of resistance to itraconazole and posaconazole and intermediate susceptibility to voriconazole. read more
December 30th, 2009
A critical care consult team can be used to rapidly recognize patients with methicillin–resistant S. aureus nasal colonization who are at very elevated risk for methicillin–resistant S. aureus infection. The use of such a team to recognize patients who have greatest potential benefit from decolonization techniques might reduce the burden of severe methicillin–resistant S. aureus infections. read more
December 21st, 2009
Brook I – Beta–lactamase–producing bacteria can play an important role in polymicrobial infections. They can have a direct pathogenic impact in causing the infection as well as an indirect effect through their ability to produce the enzyme beta–lactamase. BLPB may not only survive penicillin therapy but can also, as was demonstrated in in vitro and in vivo studies, protect other penicillin–susceptible bacteria from penicillin by releasing the free enzyme into their environment. read more
December 21st, 2009
Assadian O et al. – The unexpectedly high residual contamination despite the silver exposure represents a potential risk as recontamination source of S. aureus that could maintain the proinflammatory process in AD. This contamination is nearly completely eliminated by machine–based washing at 60°C using conventional washing powder. AD patients wearing silver textiles should change their used clothes at least daily and wash them in a washing machine at 60°C. read more
December 21st, 2009
Kaiser AM et al. – The authors study identified several clinical factors, which were associated with mortality from CDC. Future clinical studies will have to focus on the disease progression and the fatalities occurring either without an attempt for or despite surgical intervention, as an earlier intervention might have proven lifesaving. read more
