In Vitro Double and Triple Bactericidal Activities of Doripenem, Polymyxin B, and Rifampin against Multidrug-Resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli

May 26th, 2010

Urban C et al. – Bactericidal activity was achieved in 90% of all bacteria assayed using combinations of polymyxin B, doripenem, and rifampin against five each of the carbapenem–resistant Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli isolates studied. Combinations with these antibacterials may provide a strategy for treatment of patients infected with such organisms. read more

Current Microbiology of Surgical Site Infections Associated With Breast Cancer Surgery

May 26th, 2010

Rolston K et al. – Although all S aureus isolates were susceptible to vancomycin, 63% of methicillin–susceptible isolates and 82% of methicillin–resistant isolates had MIC values of > 1.0 (microgram)/mL for this agent, indicating the need for alternative therapeutic agents. The organisms were susceptible to trimethoprim/sulfamethoxazole, rifampin, linezolid, daptomycin, and tigecycline.
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Effectiveness of Alcohol-Based Hand Rubs for Removal of Clostridium difficile Spores from Hands

May 25th, 2010

Jabbar U et al. – Hand washing with soap and water is significantly more effective at removing C. difficile spores from the hands of volunteers than are ABHRs. Residual spores are readily transferred by a handshake after use of ABHR. read more

Staphylococcus aureus Nasal Colonization and Subsequent Infection in Intensive Care Unit Patients: Does Methicillin Resistance Matter

May 12th, 2010

Honda H et al. – ICU patients colonized with S. aureus were at greater risk of developing a S. aureus infection in the ICU. Even after adjusting for patient–specific risk factors, MRSA–colonized patients were more likely to develop S. aureus infection, compared with MSSA–colonized or noncolonized patients. read more

Survey of employee knowledge and attitudes before and after a multicenter Veterans’ Administration quality improvement initiative to reduce nosocomial methicillin-resistant Staphylococcus aureus infections

May 11th, 2010

Burkitt KH et al. – In this multicenter study of VA employees, implementation of a MRSA quality improvement initiative was associated with temporal improvements in knowledge and perceptions regarding MRSA prevention.
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