April 28th, 2011
Song JY et al. – All 28 isolates had the blaOXA–51–like gene with upstream ISAbaI, 2 of which additionally had the blaOXA–58–like gene and the blaOXA–23–like gene. Inoculum effect and rifampicin inducible resistance were not detected. Considering the rapid progression to death in carbapenem–resistant Acinetobacter baumannii bloodstream infections, early empirical antibiotic therapy would be warranted based on the local microbiological data in each hospital read more
April 28th, 2011
Pada SK et al. – Meticillin–resistant Staphylococcus aureus (MRSA) infection was independently associated with in–hospital death, longer length of hospitalisation, higher hospitalisation costs, higher post–discharge healthcare–associated financial costs, and poorer health–related quality of life. Outcomes were not significantly different between both hospitals. The attributable individual, institutional and societal impact of MRSA infections is considerable in Singapore. Preventing such infections will result in substantial improvements in patient outcomes and healthcare delivery. read more
April 23rd, 2011
Fukuda H et al. – Hospital–acquired infections (HAIs) present a substantial problem for healthcare providers, with a relatively high frequency of occurrence and considerable damage caused read more
April 23rd, 2011
De Kraker MEA et al. – Antimicrobial resistance is threatening the successful management of nosocomial infections worldwide. Despite the therapeutic limitations imposed by methicillin–resistant Staphylococcus aureus (MRSA), its clinical impact is still debated. read more
April 23rd, 2011
Jolivet–Gougeon A et al. – Antibiotics can also act as indirect promoters of antibiotic resistance by inducing the SOS system and certain error–prone DNA polymerases. These alterations have clinical consequences in that efficacious treatment of bacterial infections requires high doses of antibiotics and/or a combination of different classes of antimicrobial agents. There are currently few new drugs with low endogenous resistance potential, and the development of such drugs merits further research. read more
