Antimicrobial susceptibility of daptomycin and comparator agents tested against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci: trend analysis of a 6-year period in US medical centers (2005–2010)

July 7th, 2011

Sader HS et al. – Among methicillin–resistant Staphylococcus aureus (MRSA) daptomycin–non–susceptible isolates were observed with no MIC creep over the study interval. Daptomycin was very active against vancomycin–resistant E. faecalis and E. faecium. Among vancomycin–resistant enterococci (VRE), only 4 daptomycin–non–susceptible isolates (all E. faecium) were detected. In conclusion, daptomycin demonstrated sustained activity against an extensive collection of clinical isolates of MRSA and VRE from numerous US medical centers over the last 6 monitored years. read more

Mupirocin Resistance in Staphylococcus aureus Causing Recurrent Skin and Soft Tissue Infections in Children

July 3rd, 2011

McNeil JC et al. – Staphylococcus aureus resistance to mupirocin is often caused by acquisition of a novel isoleucyl–tRNA synthetase encoded on the plasmid gene mupA. read more

Geographic distribution of community-acquired methicillin-resistant Staphylococcus aureus soft tissue infections

July 3rd, 2011

Rossini CJ et al. – Methicillin–resistant Staphylococcus aureus (MRSA) has now become the most prevalent organism isolated from cultures of community–acquired abscesses requiring incision and drainage in the pediatric population in authors local region. Significant clustering of MRSA infections has appeared in several different cities within their geographic region. read more

Epidemiology and control of Clostridium difficile infections in healthcare settings: an update

July 3rd, 2011

Barbut F et al. – To prevent cross–contamination and to reduce the incidence of Clostridium difficile infection (CDI), infection control guidelines, based primarily on experience of hospitals during outbreaks, have been recently updated in Europe and the United States. read more

Increase of patients co-colonised or co-infected with methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium or extended-spectrum beta-lactamase-producing Enterobacteriaceae

July 3rd, 2011

Meyer E et al. – Patients harbouring extended–spectrum beta–lactamase (ESBL)–producing Enterobacteriaceae or vancomycin–resistant enterococci (VRE) faecium had a higher risk of being co–colonised or co–infected compared to what was to be extrapolated from their overall incidence. This might be linked to their gastrointestinal reservoir and impracticality to decolonise the gut of resistant VRE and ESBL–producing Enterobacteriaceae. read more

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