A large sustained endemic outbreak of multiresistant Pseudomonas aeruginosa: a new epidemiological scenario for nosocomial acquisition

November 26th, 2011

Suarez C et al. – In the setting of sustained multiresistant Pseudomonas aeruginosa outbreaks, epidemiological findings suggest that patients may be a reservoir for further environmental contamination and cross–transmission. Although authors control program was not successful in ending the outbreak, they think that their experience provides useful guidance for future approaches to this problem. read more

Relationships between vancomycin minimum inhibitory concentration, dosing strategies, and outcomes in methicillin-resistant Staphylococcus aureus bacteremia

November 26th, 2011

Clemens EC et al. – The treatment outcomes were similar regardless of vancomycin minimum inhibitory concentration (VAN MIC), although there was a non–statistically significant trend towards decreased clinical efficacy among patients with VAN MIC = 2 mg/L. Optimization of VAN pharmacokinetic indices did not appear to correlate with clinical responses. read more

Management of Skin and Soft Tissue Infections in Community Practice Before and After Implementing a ‘Best Practice’ Approach: An Iowa Research Network (IRENE) Intervention Study

November 26th, 2011

Daly JM et al. – The Centers for Disease Control and Prevention (CDC) algorithm was feasible for offices to use. Following a discussion of skin and soft tissue infections (SSTIs) management in the outpatient setting, use of methicillin–resistant Staphylococcus aureus (MRSA) coverage increased both initially and overall. Thus, involving clinicians in a discussion about guidelines rather than simply providing guidelines or a didactic session may be a useful way to change physician practices.
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Clinical and Molecular Characteristics of Invasive and Noninvasive Skin and Soft-Tissue Infections Caused by Group A Streptococcus

November 26th, 2011

Lin JN et al. – Dendrogram analysis showed a unique pulsed–field gel electrophoresis–SmaI pattern of emm106 that was particularly prone to cause invasive skin and soft–tissue infections. This study suggests that emm106 may be an emerging group A Streptococcus strain that causes invasive skin and soft–tissue infections. Further surveillance study to understand the significance of this invasive strain is critical read more

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