In Vitro Double and Triple Bactericidal Activities of Doripenem, Polymyxin B, and Rifampin against Multidrug-Resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli

May 26th, 2010

Urban C et al. – Bactericidal activity was achieved in 90% of all bacteria assayed using combinations of polymyxin B, doripenem, and rifampin against five each of the carbapenem–resistant Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli isolates studied. Combinations with these antibacterials may provide a strategy for treatment of patients infected with such organisms. read more

Effectiveness of Alcohol-Based Hand Rubs for Removal of Clostridium difficile Spores from Hands

May 25th, 2010

Jabbar U et al. – Hand washing with soap and water is significantly more effective at removing C. difficile spores from the hands of volunteers than are ABHRs. Residual spores are readily transferred by a handshake after use of ABHR. read more

Drug susceptibility and clonality of methicillin-resistant Staphylococcus epidermidis in hospitalized patients with hematological malignancies

May 3rd, 2010

Nomura K et al. – The results represent two significant findings. One is the major capability of MRSE to colonize patients. The other is that some MRSE isolates proved to be sensitive to clindamycin, minocycline, and cephalosporin, so that using antibiotics to which MRSE is sensitive as first–line therapy can avoid the need for vancomycin in clinical settings. read more

Contagious Period for Pandemic (H1N1) 2009

April 14th, 2010

De Serres G et al. – Human challenge studies with seasonal influenza have shown that virus shedding after day 7 is rare, but clinical studies have shown that shedding may persist beyond that period in some populations, such as elderly persons, immunocompromised patients, and children. In a study among hospitalized persons infected with seasonal influenza A viruses, 54% remained positive by PCR beyond 7 days after symptom onset, and 29% were positive by cell culture. read more

Surgical Masks for Protection of Health Care Personnel against Pandemic Novel Swine-Origin Influenza A (H1N1)- 2009: Results from an Observational Study

March 21st, 2010

Ang B et al. – There is ongoing debate about the efficacy of surgical masks versus N95 respirators for protection against pandemic novel swine–origin influenza A (H1N1)– 2009. The hospital, which is designated to manage outbreaks of emerging infection, has robust surveillance systems to detect infection in staff. read more

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