Surgical site infections in a tertiary health care center: Prospective cohort study
Suljagic V et al. – The aim of this study was to investigate the most important risk factors associated with the development of surgical site infections (SSIs). Therefore, greater attention has been given to adherence to recommendations for the prevention and control of SSIs as well as to antibiotic prophylaxis protocols read more
Targeted Surveillance of Methicillin-Resistant Staphylococcus aureus and Its Potential Use To Guide Empiric Antibiotic Therapy
Harris AD et al. – The present study aimed to determine the frequency of methicillin–resistant Staphylococcus aureus (MRSA)–positive clinical culture among hospitalized adults in different risk categories of a targeted MRSA active surveillance screening program and to assess the utility of screening in guiding empiric antibiotic therapy. The risk of MRSA infection was far higher in those who were deemed to be at high risk and who were surveillance culture positive. Targeted MRSA active surveillance may be beneficial in guiding empiric anti–MRSA therapy. read more
Determinants of carriage of resistant Staphylococcus aureus among S. aureus carriers in the Indonesian population inside and outside hospitals
Lestari ES et al. – Antibiotic policies including proper diagnosis, treatment and drug delivery process should be made by healthcare providers in Indonesia to help limit the emergence of antibiotic resistance. read more
Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus {alpha}-hemolysin-mediated cellular injury
Wilke GA et al. – These data implicate ADAM10 as the probable high–affinity toxin receptor. Upon Hla binding, ADAM10 relocalizes to caveolin 1–enriched lipid rafts that serve as a platform for the clustering of signaling molecules. It is demonstrated that the Hla–ADAM10 complex initiates intracellular signaling events that culminate in the disruption of focal adhesions.
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Emergence and Dissemination of Extended-Spectrum beta-Lactamase–Producing Escherichia coli in the Community: Lessons from the Study of a Remote and Controlled Population
Woerther PL et al. – In this population, the frequency of ESBL increased with time because of the appearance of CTX–M ESBL, mimicking what occurs in the developed world. This resulted from the probable repeated introduction of new strains and plasmids and from interindividual dissemination. During the same period, antibiotic use substantially increased.
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