The role of vitamin D deficiency in sepsis and potential therapeutic implications
Watkins RR et al. – Vitamin D is potentially an attractive therapeutic agent for sepsis given its low cost and low risk of toxicity and side effects. Further prospective, randomized, controlled clinical trials of adjunctive vitamin D therapy in patients who are deficient are needed in the management of human sepsis syndrome. read more
Antimicrobial Resistance in Urinary Tract Pathogens in Canada from 2007 to 2009: CANWARD Surveillance Study
Karlowsky JA et al. – Increased age was also associated with resistance to ciprofloxacin and with resistance to two or more commonly prescribed oral agents (amoxicillin–clavulanate, ciprofloxacin, nitrofurantoin, and sulfamethoxazole). The authors conclude that frequently prescribed empirical agents for urinary tract infections, such as sulfamethoxazole and ciprofloxacin, demonstrate lowered in vitro susceptibilities when tested against recent clinical isolates. read more
Antimicrobial susceptibility of daptomycin and comparator agents tested against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci: trend analysis of a 6-year period in US medical centers (2005–2010)
Sader HS et al. – Among methicillin–resistant Staphylococcus aureus (MRSA) daptomycin–non–susceptible isolates were observed with no MIC creep over the study interval. Daptomycin was very active against vancomycin–resistant E. faecalis and E. faecium. Among vancomycin–resistant enterococci (VRE), only 4 daptomycin–non–susceptible isolates (all E. faecium) were detected. In conclusion, daptomycin demonstrated sustained activity against an extensive collection of clinical isolates of MRSA and VRE from numerous US medical centers over the last 6 monitored years. read more
Mupirocin Resistance in Staphylococcus aureus Causing Recurrent Skin and Soft Tissue Infections in Children
McNeil JC et al. – Staphylococcus aureus resistance to mupirocin is often caused by acquisition of a novel isoleucyl–tRNA synthetase encoded on the plasmid gene mupA. read more
Geographic distribution of community-acquired methicillin-resistant Staphylococcus aureus soft tissue infections
Rossini CJ et al. – Methicillin–resistant Staphylococcus aureus (MRSA) has now become the most prevalent organism isolated from cultures of community–acquired abscesses requiring incision and drainage in the pediatric population in authors local region. Significant clustering of MRSA infections has appeared in several different cities within their geographic region. read more
